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MOTS-C is an exercise-mimetic peptide that activates AMPK and is reported in animal models to prevent ovariectomy-induced obesity and insulin resistance

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Besides, each of the tested gut-brain peptides modulates the behavioral and neurochemical responses induced by additive drugs as well as drug-taking for other drugs than alcohol (for example nicotine, cocaine, and amphetamine), which are not influenced by ingestion or calories [for review see (115)]

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